Neurotoxic effects of occupational exposure to organotins

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Abstract
Twenty-two chemical workers were given neurological, psychiatric and neuropsychological examinations and placed in 1 of 2 groups according to their degree of exposure to trimethyltin chloride spillage during Jan. 1978. Other chemicals to which they had been exposed were dimethyltin dichloride and methyl chloride. Specific and nonspecific symptoms of intoxication of the CNS showed a significantly greater frequency in the highly exposed group, including cycles of depression and destructive rage, each lasting a few hours. These observations should alert diagnosticians to this type of occupational exposure.