Proton MR spectroscopy for monitoring early treatment response of breast cancer to neo-adjuvant chemotherapy

Abstract
With respect to treatment monitoring, conventional modalities such as physical examination, ultrasonography, and mammography are frequently used, but vary in reliability for measuring tumor's therapeutic response [1, 2]. Magnetic resonance imaging (MRI) is increasingly being used to evaluate locally advanced breast cancer undergoing neo-adjuvant chemotherapy. However, changes in lesion size or dynamic contrast enhanced MRI are not detected until several weeks following chemotherapy [3].