PICOSECOND FLUORESCENCE SPECTROSCOPY ON INCORPORATION PROCESSES OF HEMATOPORPHYRIN DERIVATIVE INTO MALIGNANT TUMOR CELLSin vitro

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Abstract
Abstract—By using a highly sensitive streak‐camera technique, we investigate incorporation processes of HpD into malignant tumor m‐KSA cellsin vitro.The picosecond decays of the total fluorescence spectra, the wavelength‐resolved fluorescence decays and the time‐resolved fluorescence spectra from HpD in the cells are measured as a function of the incubation time. The results show that the aggregate component of HpD which has a fast fluorescence lifetime of 100 ps and a red‐shifted band of ∼ 660 nm selectively accumulates more and more in the cells with the increase of the incubation time.