Neuronally mediated non-cholinergic contraction of guineapig bronchial smooth muscle is inhibited by a substance P antagonist
- 1 May 1984
- journal article
- Published by Springer Nature in Inflammation Research
- Vol. 14 (3-4) , 315-318
- https://doi.org/10.1007/bf01973819
Abstract
The isolated main bronchi of the guinea-pig respond to electrical field stimulation with a twitch followed by a slow contraction. Atropine blocked the slow contraction. The substance P antagonist, (d-Pro2,d-Trp7.9)-SP, greatly reduced the atropine-resistant contraction. The results suggest the involvement of substance P in non-cholinergic neurotransmission in the guinea-pig airways.Keywords
This publication has 12 references indexed in Scilit:
- Substance P antagonists release histamine from peritoneal mast cellsActa Physiologica Scandinavica, 1983
- Peptide-containing nerve fibres in the airways: distribution and functional implications.1983
- Bronchial smooth muscle contraction induced by stimulation of capsaicin‐sensitive sensory neuronsActa Physiologica Scandinavica, 1982
- THE MECHANISM OF ACTION OF A SUBSTANCE P ANTAGONIST (D-Pro2, D-Trp7,9)-SPBritish Journal of Pharmacology, 1982
- Regulatory Peptides in the Mammalian Respiratory Tract*Endocrinology, 1982
- A specific substance P antagonist blocks smooth muscle contractions induced by non-cholinergic, non-adrenergic nerve stimulationNature, 1981
- Pharmacological Characterization of the Autonomous Innervation of the Guinea Pig Tracheobronchial Smooth MuscleActa Pharmacologica et Toxicologica, 1981
- Occurrence and Distribution of Vip Nerves in the Nasal Mucosa and Tracheobronchial WallActa Oto-Laryngologica, 1978
- Tetrodotoxin, saxitoxin and their significance in the study of excitation phenomena.1966