Inhibition of Human Platelet Aggregation by a Dibenzazepine Compound (GP 44296) and by N-(2,6-dichlorophenyl)-o-aminophenylacetic acid(GP 45840)
- 1 May 1971
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 49 (5) , 479-481
- https://doi.org/10.1139/y71-058
Abstract
Studies of the aggregation of human platelets indicate that compounds GP 44296 and GP 45840 inhibit the secondary phase of ADP-induced aggregation and collagen-induced aggregation; GP 44296 also inhibits the primary phase of ADP-induced aggregation. Our results suggest that these compounds are more active on platelet behavior in vitro than phenylbutazone, oxyphenbutazone, and sulfinpyrazone.Keywords
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