Characterization of Tachykinin Receptors in Urinary Bladder from Guinea Pig
Open Access
- 1 January 1990
- journal article
- research article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 54 (2) , 241-243
- https://doi.org/10.1254/jjp.54.241
Abstract
The contractile responses to substance P (SP), neurokinin A (NKA), Tyro-neurokinin B (Tyr-NKB), senktide (NK3 receptor selective agonist) and SP methyl ester (SPOMe, NK1 receptor selective agonist) were investigated in detrusor strips from guinea pigs. Except for senktide, all drugs induced a concentration-related contraction with the following rank order of potency: SPOMe > SP > NKA .gtoreq. Tyr-NKB. After desensitization of NK1 receptors with SPOMe, the rank order of potency was NKA .gtoreq. Tyr-NKB > SP > SPOMe. Both NK1 and NK2 receptors exist in the detrusor strip from guinea pigs.This publication has 13 references indexed in Scilit:
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