Prostaglandins. Part 4. Synthesis of (±)-11-deoxyprostaglandins from 2-(ω-hydroxyheptyl)cyclopent-2-enones
- 1 January 1976
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 23,p. 2550-2556
- https://doi.org/10.1039/p19760002550
Abstract
Conjugate nitrile addition to 2-(7-hydroxyheptyl)cyclopent-2-enone (IIIa) and subsequent elaboration via the aldehydes [(VIa), (Xa)] affords a convenient direct route to (±)-11-deoxyprostaglandins of the E1 and F1 series. Syntheses of (±)-10-methyl- and (±)-α-nor-11-deoxyprostaglandins are also described.This publication has 0 references indexed in Scilit: