Second-Trimester Abortion by Intramuscular 15-Methyl-Prostaglandin F2$alpha; or Intravaginal Prostaglandin E2 Suppositories: A Randomized Trial
- 1 May 1995
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Obstetrics & Gynecology
- Vol. 85 (5) , 697-700
- https://doi.org/10.1016/0029-7844(95)00011-f
Abstract
Objective: To compare intramuscular (IM) prostaglandin 15 methyl-F2α (15M-PGF2α) with prostaglandin E2 (PGE2) vaginal suppositories for second-trimester abortion in terms of efficacy and side effects. Methods: Fifty-one women were randomized to receive either 15M-PGF2α IM injections or PGE2 intravaginal suppositories for second-trimester abortion. Efficacy and side effects of the two agents were analyzed by two-tailed t tests, χ2 analysis with Fisher exact test, and survival analysis. Results: The mean times to rupture of membranes, delivery of fetus, and delivery of placenta were significantly less for women receiving PGE2 vaginal suppositories. The cumulative abortion rate after 24 hours for the PGE2 group was 96%, compared with 69% for the 15M-PGF2α group. Although there were few differences in side effects, the 15MPGF2α group had significantly fewer headaches, fevers, and chills. Conclusion: Intravaginal PGE2 is superior to IM 15MPGF2α for second-trimester abortion.Keywords
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