Hemagglutination-inhibiting antibodies in vaccinated children with renal disease

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Abstract
One yr after immunization with a single 0.5-ml dose of influenza virus vaccine, serum samples from 30 children with renal diseases were tested for serum hemagglutination-inhibiting (HI) antibody titers to A/New Jersey/76, A/Victoria/75 and A/USSR/77. Unvaccinated children (11) with renal diseases formed a comparison group. In contrast to the comparison group (0/11), 53% (16/30) of the vaccinated group had a protective level of serum HI titers (.gtoreq. 1:40) against A/New Jersey. A protective level of serum HI titer against A/Victoria was noted in 83% (25/30) of the vaccinated group, while 54% (6/11) of the unvaccinated group had similar HI titers. None had a detectable HI titer against A/USSR. A minor common cold-like illness occurred in 7 of the 30 vaccinated children; 1 had exacerbation of nephrotic syndrome. Good protection against influenza was apparently obtained 1 yr after vaccination in children with renal disease.