The complete nucleotide sequence of the I-Eαdimmune response gene
Open Access
- 11 August 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 11 (15) , 5055-5071
- https://doi.org/10.1093/nar/11.15.5055
Abstract
We have isolated and sequenced the complete muring I-Ea immune response gene of the H-2a haplotype. The I-Ea gene consists of 5300 basepairs and is organized into five or possibly six exons that correspond to different domains of the a chain. The amino acid sequence deduced from the I-Ea gene shows 75% homology to its human counterpart, the HLA-DR a chain. The absence of I-E antigen in H-2a mice is due to lack of Ea chain synthesis. We show here that this defect is caused by a deletion in the 5' end of the I-Eabgene.Keywords
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