The Differential Action of Irradiated and Chemically Treated Marrow on Survival and on Thymic Regeneration in Irradiated Mice

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Abstract
Bone marrow from X-rayed, thio-TEPA-, and urethan-treated donors failed to promote thymic regeneration in sublethally irradiated animals, whereas the same number of cells from the same marrow pools were effective in protecting against the effects of lethal irradiation. It is concluded that there are at least 2 mechanisms of action by which bone marrow independently promotes thymic regeneration and survival in X-irradiated animals. It is considered unlikely that isologous bone marrow promotes thymic regeneration simply by repopulating the irradiated thymus gland.