INDUCTION OF MALE SEXUAL BEHAVIOUR BY OESTRADIOL BENZOATE IN COMBINATION WITH DIHYDROTESTOSTERONE

Abstract
The capacity of oestrogen to activate sexual behaviour in castrated male rats has been reported repeatedly (see Davidson & Bloch, 1969; Pfaff, 1970). The mating pattern observed after oestrogen treatment is mostly incomplete, intromission and ejaculation patterns being infrequent or entirely absent. A possible reason for the deficiencies seen in the mating pattern of the castrated, oestrogen-treated males is an insufficient development of the penis since oestrogen does not stimulate normal growth of the accessory sex organs (Price & Williams-Ashman, 1961). The present communication reports a study in which castrated rats, given oestradiol benzoate (EB), were treated additionally with 5α-androstan-17β-ol-3-one (dihydrotestosterone, DHT), a metabolite of testosterone which is highly potent in stimulating penile and accessory sexual organ growth but has little, if any, stimulatory effect upon sexual behaviour (Feder, 1971; Whalen & Luttge, 1971). Male rats were castrated at 30 days of age and treated as follows: Group A rats