Studies on Lewis Acid-Catalysed Generation and Intermolecular Trapping of Chiral Stabilised Azomethine Ylids

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Abstract
Preparation of the ylid (2) derived from 5(R)-phenylmorpholinone (1) in the presence of freshly prepared MgBr2·Et2O and dipolarophiles can lead to improved cycloaddition yields, with inverse diastereo- and regioselection compared to the corresponding uncatalysed reactions.