PROSPECTIVE-STUDY OF PLASMA DNA IN DIAGNOSIS OF PULMONARY-EMBOLISM
- 1 January 1978
- journal article
- research article
- Published by Elsevier
- Vol. 118 (3) , 475-478
- https://doi.org/10.1164/arrd.1978.118.3.475
Abstract
To assess the usefulness of plasma DNA detection in the diagnosis of pulmonary embolism (PE), the frequency and duration of the occurrence of free plasma DNA was studied in 23 patients with PE and in 49 patients with pneumonia, myocardial infarction, thrombophlebitis, or normal lung scans. Plasma DNA was detected in 19 of the 23 patients (83%) with PE and in none of the 49 patients with other diagnoses. Of the 19 PE patients with free DNA, 18 had persistence of DNA on all subsequent sampling for up to 5 days. In this series, plasma DNA had a sensitivity of 83% in the diagnosis of PE and was extremely specific for PE. Detection of free plasma DNA may be useful as a rapid, noninvasive test to aid in the diagnosis of PE.This publication has 2 references indexed in Scilit:
- Fibrin Split Products in Acute Pulmonary EmbolismAnnals of Internal Medicine, 1973
- Diagnostic Sensitivity of Laboratory Findings in Acute Pulmonary EmbolismAnnals of Internal Medicine, 1971