Effect of prolonged exercise at altitude on the renin-aldosterone system
- 1 August 1983
- journal article
- research article
- Published by American Physiological Society in Journal of Applied Physiology
- Vol. 55 (2) , 413-418
- https://doi.org/10.1152/jappl.1983.55.2.413
Abstract
The combined effect of exercise and altitude on the renin-aldosterone system was studied in six male subjects on a fixed diet. After 4 control days at rest and at low altitude, subjects ascended to 3,100 m and took about 7 h exercise daily for 5 days. There followed a 4-day recovery period at low altitude. Daily blood samples were taken for estimation of plasma renin activity (PRA), plasma aldosterone concentration (PAC), and angiotensin converting-enzyme (ACE) activity. Results showed a maximal rise in PRA and PAC with exercise at altitude maximal on the first 2 days. ACE activity fell by 23% at altitude. Compared with similar exercise at sea level, the rise in PAC was comparable but the rise in PRA was four times greater, indicating a marked decrease in PAC response to PRA. It is suggested that this loss of sensitivity of PAC to PRA is mediated by the measured reduction in ACE activity.This publication has 3 references indexed in Scilit:
- Fluid and electrolyte homeostasis during prolonged exercise at altitudeJournal of Applied Physiology, 1983
- Inhibition of converting enzyme activity by acute hypoxia in dogsJournal of Applied Physiology, 1979
- The kidney and aldosterone in acclimatization at altitudeRespiratory Medicine, 1977