Potential tissue selectivity of dietary phytoestrogens and estrogens

1 February 1999

journal article
review article
Published by Wolters Kluwer Health in Current Opinion in Lipidology

Vol. 10 (1) , 47-52
https://doi.org/10.1097/00041433-199902000-00009

Abstract

The recent discovery of a second estrogen receptor subtype, estrogen receptor-beta, may significantly advance our understanding of tissue specific effects of estrogenic compounds, both natural and synthetic. Although specific effects mediated by estrogen receptor beta in vivo remain to be elucidated, hypothetically the existence of two estrogen receptor subtypes (differing in both tissue distribution and biological activity) may help to explain the curious pharmacological behaviour of many estrogenic and antiestrogenic compounds, including the naturally occurring dietary phytoestrogens.

Keywords

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