Liquid-chromatographic detection of aspartylglycosaminuria.
Open Access
- 1 March 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 32 (3) , 501-502
- https://doi.org/10.1093/clinchem/32.3.501
Abstract
We describe a specific, simple liquid-chromatographic method for detecting the lysosomal storage disease aspartylglycosaminuria. The method is based on identification and quantification of the major storage compound 2-acetamido-1-L-beta-aspartamido-1, 2-dideoxy-beta-D-glucose in the urine of affected individuals. Sample preparation and chromatographic analysis requires 30 min. Within-day variation of the method was less than 4.4%, between-day variation less than 11.7% (n = 10 each).This publication has 4 references indexed in Scilit:
- Detection of aspartylglycosaminuria by gas--liquid chromatography.Clinical Chemistry, 1981
- QUANTITATIVE-DETERMINATION OF 4-N-2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSYL-L-ASPARAGINE IN THE URINE OF PATIENTS WITH ASPARTYLGLYCOSAMINURIA BY GAS-LIQUID-CHROMATOGRAPHY1979
- Enzymatic determination of urinary aspartylglycosylamine: A rapid and sensitive method to detect aspartylclycosylaminuria (AGU)Clinica Chimica Acta; International Journal of Clinical Chemistry, 1976
- Enzymatic Diagnosis and Carrier Detection of Aspartylglucosaminuria Using Blood SamplesPediatric Research, 1976