DETERMINATION OF ANTAZOLINE IN DOSAGE FORMS AND WITH NAPHAZOLINE IN COMBINATION

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Abstract
A simple and rapid spectrophotometric method is described for the determination of antazoline and naphazoline either singly or in combination. The method is based on the interaction of both drugs in the form of base with chloranil in acetonitrile at room temperature. The interaction products of antazoline and naphazoline exhibit two lmax, one at about 300 nm for both drugs and the other at 448 and 510 nm for antazoline and naphazoline respectively. Different variables have been studied to optimize the reaction conditions for both drugs. Beer's law is obeyed for both drugs over a range of 5-45 mg/ml. Interference studies are carried out and the application of this procedure for the determination of antazoline in single component tablets and in combination with naphazoline in nasal drops is given with good recovery range(99.4-99.9%). Synthetic mixtures of antazoline and naphazoline are satisfactorily analyzed simultaneously with good recoveries.

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