Alanine-scanning Mutagenesis of a Putative Substrate Recognition Site in Human Cytochrome P450 3A4
Open Access
- 1 February 1997
- journal article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 272 (9) , 5396-5402
- https://doi.org/10.1074/jbc.272.9.5396
Abstract
No abstract availableKeywords
This publication has 40 references indexed in Scilit:
- Cytochrome P-450 hPCN3, a Novel Cytochrome P-450 IIIA Gene Product That Is Differentially Expressed in Adult Human Liver: cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporinPublished by Elsevier ,2021
- Role of Residue 480 in Substrate Specificity of Cytochrome P450 2B5 and 2B11Archives of Biochemistry and Biophysics, 1996
- Oxidation of Aflatoxin B1 by Bacterial Recombinant Human Cytochrome P450 EnzymesChemical Research in Toxicology, 1995
- Activation of CYP3A4: Evidence for the Simultaneous Binding of Two Substrates in a Cytochrome P450 Active SiteBiochemistry, 1994
- Predicting the cytochrome P450 mediated metabolism of xenobioticsPharmacogenetics, 1993
- Oxidation of aflatoxins and sterigmatocystin by human liver microsomes: significance of aflatoxin Q1 as a detoxication product of aflatoxin B1Chemical Research in Toxicology, 1992
- Characterization of human cytochrome P450 enzymesThe FASEB Journal, 1992
- Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450sArchives of Biochemistry and Biophysics, 1991
- Mechanism-based inactivation of human liver microsomal cytochrome P-450 IIIA4 by gestodeneChemical Research in Toxicology, 1990
- Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver.Proceedings of the National Academy of Sciences, 1989