Dicer is essential for mouse development
Top Cited Papers
- 5 October 2003
- journal article
- research article
- Published by Springer Nature in Nature Genetics
- Vol. 35 (3) , 215-217
- https://doi.org/10.1038/ng1253
Abstract
To address the biological function of RNA interference (RNAi)-related pathways in mammals, we disrupted the gene Dicer1 in mice. Loss of Dicer1 lead to lethality early in development, with Dicer1-null embryos depleted of stem cells. Coupled with our inability to generate viable Dicer1-null embryonic stem (ES) cells, this suggests a role for Dicer, and, by implication, the RNAi machinery, in maintaining the stem cell population during early mouse development.Keywords
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