N,N-Dimethylglycine for Epilepsy

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Abstract
To the Editor: Despite the development of new anticonvulsant agents in recent years, many epileptic patients continue to have seizures. We recently saw a patient who had an apparent dramatic reduction in his seizure frequency after starting N,N-dimethylglycine (DMG). DMG is produced by dual methylation of the nitrogen moiety of glycine, and is a normal body constituent formed in the metabolism of homocysteine to methionine. It is commercially available without a prescription in many health-food stores.Our patient was a 22-year-old man who presented with long-standing mental retardation and mixed complex, partial, and grand mal seizures. Other than . . .