Excretion of Pregnan-3 , 17 , 21-Triol-20-One (Tetrahydro S) by Patients with Adrenocortical Carcinoma.
- 1 November 1958
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 99 (2) , 285-287
- https://doi.org/10.3181/00379727-99-24324
Abstract
In 5 patients with adrenocortical carcinoma and high excretion of Porter Silber chromogens, the excretion of tetrahydro S was likewise elevated. These patients excreted from 7 to 44 mg/24 hours. Dihydro S was presumptively identified in the urine of 1 of these patients. When an adrenocortical carcinoma produced only 17-ketosteroids, tetrahydro S excretion was normal. It is suggested that 11-beta hydroxylation is the rate limiting step in the synthesis of hydrocortisone by adrenocortical carcinomas producing hydrocortisone.Keywords
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