Metabolism of C14-Diethylstilbestrol in the Chicken: Retention and Excretion
- 1 June 1962
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 70 (6) , 880-885
- https://doi.org/10.1210/endo-70-6-880
Abstract
Cockerels were each implanted with 1 μc diethyl(ethyl-l-C14)stilbestrol at 15 mg per bird. The uptake and the retention of radioactivity by various tissues were determined over periods ranging from 4 hours to 30 days. Thirty per cent of the total dose was absorbed from the injection site (head and neck) in 4 hours. The half-life of the hormone in the chicken was between 2 and 3 days. At terminus, the injection site, liver, bile, blood, ingesta, leg and wings had radioactivity totaling 0.7% of the administered dose. Excreta (feces-urine) were collected daily and assayed for biologic and radioactivity. Of the total radioactivity, 29% was excreted in 24 hours, 70% in 11 days, and 74% after 30 days. The estrogenic activity of the administered hormone recovered in the fecesurine was only 48 % of the radioactivity.Keywords
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