Caudwell Xtreme Everest: a field study of human adaptation to hypoxia
Open Access
- 1 January 2007
- journal article
- editorial
- Published by Springer Nature in Critical Care
- Vol. 11 (4) , 151
- https://doi.org/10.1186/cc5921
Abstract
Caudwell Xtreme Everest (CXE) is a large healthy volunteer field study investigating human adaptation to environmental hypoxia. More than 200 individuals were studied at sea-level and in four laboratories on the trek to Everest Base Camp (5,300 m). Fifteen physicians climbed high on Everest and continued the studies as they ascended; eight of these individuals reached the summit of Everest and succeeded in sampling arterial blood at 8,400 m on their descent. Core measurements included cardiopulmonary exercise testing, neuropsychological assessment, near infra-red spectroscopy of brain and exercising muscle, blood markers and daily recording of simple physiological variables. The goal of CXE is to further our understanding of human adaptation to cellular hypoxia, a fundamental mechanism of injury in critical illness, with the aim of improving the care of critically ill patients.Keywords
This publication has 9 references indexed in Scilit:
- High-altitude physiology and pathophysiology: implications and relevance for intensive care medicineCritical Care, 2007
- Bench-to-bedside review: Potential strategies to protect or reverse mitochondrial dysfunction in sepsis-induced organ failureCritical Care, 2006
- Early goal-directed therapy after major surgery reduces complications and duration of hospital stay. A randomised, controlled trial [ISRCTN38797445]Critical Care, 2005
- Performance at altitude and angiotensin I-converting enzyme genotypeEuropean Journal of Applied Physiology, 2004
- Bench-to-bedside review: Cytopathic hypoxiaPublished by Institute of Electrical and Electronics Engineers (IEEE) ,2002
- Angiotensin Converting Enzyme Insertion/Deletion Polymorphism Is Associated with Susceptibility and Outcome in Acute Respiratory Distress SyndromeAmerican Journal of Respiratory and Critical Care Medicine, 2002
- Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic ShockNew England Journal of Medicine, 2001
- Angiotensin-converting-enzyme gene insertion/deletion polymorphism and response to physical trainingThe Lancet, 1999
- Response of Critically III Patients to Treatment Aimed at Achieving Supranormal Oxygen Delivery and ConsumptionChest, 1993