STIMULATION OF RAT ADRENOCORTICAL SECRETION BY A FACTOR PRESENT IN HUMAN URINE
- 1 May 1959
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 64 (5) , 631-637
- https://doi.org/10.1210/endo-64-5-631
Abstract
Production of corticosteroids by the rat adrenal gland has been studied in vitro. Both a commercial and a highly purified preparation of ACTH stimulated the secretion of "corticosterone" and aldosterone in vitro. The "corticosterone" fraction was increased more than aldosterone. Addition of the non-ultrafilterable fraction of human urine to the incubate stimulated the secretion of aldosterone more than "corticosterone". Several possible interpretations of this effect are discussed.Keywords
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