SA Gene and Blood Pressure Cosegregation Using Dahl Salt-Sensitive Rats

1 April 1993

journal article
research article
Published by Oxford University Press (OUP) in American Journal of Hypertension

Vol. 6 (4) , 330-334
https://doi.org/10.1093/ajh/6.4.330

Abstract

Based on the published cDNA base sequence for the (anonymous) S^A gene, a polymerase-chain-reaction (PCR) product from the S^A gene was obtained from a Dahl salt-sensitive rat kidney cDNA library. Compared to the published sequence, this product had a 102 base pair insert in the 3' end of the cDNA, probably as the result of alternate mRNA splicing. A Stul restriction fragment length polymorphism detected three alleles among various rat strains using this PCR S^A gene probe. Alleles at the S^A locus strongly cosegregated with blood pressure (P = .0012) in a salt-fed F² population derived from crossing Dahl S and Lewis rats. In contrast, a cosegregation analysis of blood pressure and S^A alleles in salt-fed F² rats derived from a Dahl S X Wistar- Kyoto cross gave a negative cosegregation result. It is concluded that in certain genetic backgrounds the S^A gene (or a closely linked gene) can contribute a significant component of genetic hypertension. Am J Hypertens 1993;6:330–334

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