Urinary Excretion Kinetics of Salicyluric Acid.

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Abstract
Summary The data obtained in both man and dog indicate that the excretion of salicyluric acid following i.v. injection of the compound can be described as fitting an open, mammillary 2-compartment system. The data indicate, in agreement with the findings of other investigators, that the excretion of salicyluric acid following administration of acetylsalicylate or salicylate is limited by the ability to conjugate salicylate with glycine rather than the excretion capacity of the kidney. Indirect measurement of the rate of synthesis of salicylurate after oral administration of acetylsalicylate by measurement of the rate of salicylurate excretion may be useful as an index of liver function. The procedure is simple and the analytical techniques are easily automated.

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