Prevention of Rh Isoimmunization
- 6 February 1967
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 199 (6) , 390-394
- https://doi.org/10.1001/jama.1967.03120060088014
Abstract
Many workers have shown conclusively that passive antibody is capable of specific immunosuppression of the active immunity that follows injection of an antigen.1-18It is also clear from experimental results in mice that specific IgG antibody is from 100 to 200 times more immunosuppressive than specific IgM antibody.18No attempts had been made to apply this very real immunological phenomenon as a means of immunosuppression for a practical purpose until in 1960 three of the authors (V.J.F., J.G.G., and W.P.) began a program to explore the possibilities of using passive antibody to prevent Rh-negative mothers from becoming immunized by Rh-positive fetuses.19-29Our specific hope that the method might work for Rh was supported by the implications of Levine's observations30and by actual experimental data of Stern et al,31that circulating anti-A and anti-B antibodies actually do prevent Rh-negative mothers from being sensitized to the RhKeywords
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