The Hydrophobic Domain of the Mycobacterial Erp Protein Is Not Essential for the Virulence of Mycobacterium tuberculosis
- 1 April 2004
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 72 (4) , 2379-82
- https://doi.org/10.1128/iai.72.4.2379-2382.2004
Abstract
Erp (exported repetitive protein) is a member of a mycobacterium-specific family of extracellular proteins. A hydrophobic region that is localized at the C-terminal domain and that represents a quarter of the protein is highly conserved across species. Here we show that this hydrophobic region is not essential for restoring the virulence and tissue damage of an erp :: aph mutant strain of M. tuberculosis as assessed by bacterial counts and lung histology analysis in a mouse model of tuberculosis.Keywords
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