Induced Collagenolytic Activity by Electrical Stimulation of Embryonic Fibroblasts in Tissue Culture
- 1 November 1974
- journal article
- research article
- Published by SAGE Publications in Journal of Dental Research
- Vol. 53 (6) , 1475-1483
- https://doi.org/10.1177/00220345740530063001
Abstract
Continuous electrical stimulation (3.5 μ amp; 1 sine wave cycle per second) of tissue culture human embryonic fibroblasts in the presence of HCL demineralized bone significantly transformed the normal cells. After 8 to 12 days of stimulation, the cells lost the capacity to form sheets; the central nucleus moved peripherally and the cells acted as phagocytes; and multinuclear cells in association with bone showed osteoclastlike properties.Keywords
This publication has 20 references indexed in Scilit:
- Electrical Behavior of Cartilage during LoadingScience, 1972
- Bone Resorption Induced by Epithelial and Connective Tissue from Human Gingiva In VitroJournal of Dental Research, 1972
- Bone Growth in Organ Culture Modified by an Electric FieldJournal of Dental Research, 1972
- Electric Enhancement of Bone HealingScience, 1972
- Stimulation of Partial Limb Regeneration in RatsNature, 1972
- Collagenolysis in Cultured Tissue: I. Digestion of Mesenteric Fibers by Enzymes from Explanted Gingival TissueJournal of Dental Research, 1971
- Piezoelectric Effect and Growth Control in BoneNature, 1970
- Biologic significance of piezoelectricityCalcified Tissue International, 1967
- A METHOD FOR PRODUCING CELLULAR DEDIFFERENTIATION BY MEANS OF VERY SMALL ELECTRICAL CURRENTS*Transactions of the New York Academy of Sciences, 1967
- Piezoelectricity as a Fundamental Property of Biological TissuesNature, 1967