Attacking pain at its source: new perspectives on opioids
Top Cited Papers
- 31 July 2003
- journal article
- review article
- Published by Springer Nature in Nature Medicine
- Vol. 9 (8) , 1003-1008
- https://doi.org/10.1038/nm908
Abstract
The treatment of severe pain with opioids has thus far been limited by their unwanted central side effects. Recent research promises new approaches, including opioid analgesics acting outside the central nervous system, targeting of opioid peptide–containing immune cells to peripheral damaged tissue, and gene transfer to enhance opioid production at sites of injury.Keywords
This publication has 95 references indexed in Scilit:
- μ Opioid receptors and analgesia at the site of a peripheral nerve injuryAnnals of Neurology, 2003
- No pain, no gain: clinical excellence and scientific rigour – lessons learned from IA morphinePain, 2002
- Chemical coding of neurons expressing δ- and κ-opioid receptor and type I vanilloid receptor immunoreactivities in the porcine ileumCell and tissue research, 2002
- Regulation of μ-Opioid Receptor Gene Transcription by Interleukin-4 and Influence of an Allelic Variation within a STAT6 Transcription Factor Binding SitePublished by Elsevier ,2001
- Local Administration of Morphine for Analgesia after Iliac Bone Graft Harvest:RetractedAnesthesiology, 2001
- Modulation of CGRP and PGE2 release from isolated rat skin by α-adrenoceptors and α-opioid-receptorsNeuroReport, 2001
- Morphine inhibits the release of tumor necrosis factor in human peripheral blood mononuclear cell culturesInternational Journal of Immunopharmacology, 1993
- Intraarticular Morphine, Bupivacaine, and Morphine/Bupivacaine for Pain Control after Knee VideoarthroscopyAnesthesiology, 1992
- Peripheral effect of fentanyl upon nociception in inflamed tissue of the ratNeuroscience Letters, 1988
- Multiple opiate receptor sites on primary afferent fibresNature, 1980