Responses of the Denervated Rat Urinary Bladder to Alfa Adrenoceptor Stimulation

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Abstract
Elmér, M.Responses of the denervated rat urinary bladder to alfa adrenoceptor stimulation. Acta physiol. scand. 1976.98. 440–444.The contractile responses of the rat detrusor muscle to noradrenaline were increased 2–3 weeks after partial denervation but had returned to control values 6–9 weeks after the denervation, probably because of reinnervation of denervated muscle cells. 6–9 weeks after partial denervation the excitatory cr‐adreno‐ceptor mediated response to stimulation of the remaining intact nerves was predominant, masking the subsequent inhibitory β‐receptor response, which at this time was seen only after α‐receptor blockade. The possibility of an outgrowth of adrenergic fibres activating a‐receptors in muscle cells normally not innervated by adrenergic nerves is discussed.