THE METABOLISM OF IODOTYROSINES. III. DI-IODOTYROSINE DESHALOGENATING ACTIVITY OF HUMAN THYROID TISSUE

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Abstract
Deshalo-genation of Il31-labeled di-iodotyrosine was demonstrated in sheep and bovine thyroid tissue slices, and in thyroid tissue from 5 patients with nodular goiter and 1 with treated Graves'' disease. Thyroid tissue slices from a patient with familial goitrous cretinism failed to deshalogenate labeled di-iodotyrosine. The metabolic disorder of the patient with familial cretinism and that of similar patients is conceived as a general somatic failure of the normal process of deshalogenation of mono- and di-iodotyrosine. The hypothyroid state and the hyper-plastic goiter are presumed to result from the loss of hormone precursors from the thyroid and from the body.