THE PASSAGE OF PROTEINS FROM THE VASCULAR SYSTEM INTO JOINTS AND CERTAIN OTHER BODY CAVITIES

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Abstract
The expts. were undertaken to study comparatively the transference of certain foreign proteins from the blood stream into joints, aq. humor, spinal fluid, and urine. Crystalline egg albumin or horse serum protein fractions were injected intravenously into rabbits. By employing the precipitin test with specified antisera as a means for their detection, these proteins were shown to pass regularly, within a short period of time, from the blood stream into the joints. They also appeared in the aq. humor, but in lower conc. In the majority of expts., no foreign protein was detected in the spinal fluid; when present its conc, was never more than minimal. Egg albumin was rapidly passed via the kidney, whereas horse serum proteins were only occasionally detected in low conc, in the urine. These expts., demonstrating that the synovial membrane was more permeable to the foreign proteins employed than were the membranes separating the aqueous humor and spinal fluid from the vascular system, explained the higher homologous protein conc, of normal synovial fluid as compared with spinal fluid and aqueous humor and the very high protein conc, found in long-standing joint effusions.

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