Myocardial Lactate Metabolism in Coronary Insufficiency

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Abstract
Sixty five patients were studied by coronary sinus catheterization at rest and during the stresses of exercise and isoproterenol infusion. Thirty-one had clinical coronary insufficiency. A much higher incidence of abnormalities suggesting myocardial anaerobic metabolism was seen in the coronary insufficiency group as compared with the control group. Abnormal lactate metabolism was detected in 2 or more states in 21 subjects. Fifteen, or 72%, had coronary insufficiency.