Locus for Susceptibility to Melanoma on Chromosome 1p

Publisher Website
Google Scholar
Abstract
Bale and coworkers reported in the May 25 issue1 that they had localized the gene for hereditary cutaneous malignant melanoma—dysplastic nevus (dysplastic nevus syndrome) to the distal part of the short arm of chromosome 1 (1p36) in a region between an anonymous DNA marker (D1S47) and the gene locus for pronatrodilatin (PND). The D1S47 and the PND probes gave positive lod scores of 3.62 (Θ = 0.107) and 3.09 (Θ = 0.08), respectively. To address the question of whether there is a locus for susceptibility to melanoma on chromosome 1p in Dutch families with dysplastic nevus syndrome, we analyzed the linkage between the locus for cutaneous malignant melanoma or dysplastic nevus or both and the D1S47 and PND loci in six large families with the syndrome.2 The gene for the dysplastic nevus syndrome was found to be clinically nonpenetrant in about 15 percent of the subjects proved to carry the gene, with a gene frequency of 0.003.