Effect of repeated treatment with antidepressant drugs and electroconvulsive shock (ECS) on [3H] prazosin binding to different rat brain structures
- 1 February 1988
- journal article
- conference paper
- Published by Springer Nature in Journal Of Neural Transmission-Parkinsons Disease and Dementia Section
- Vol. 71 (1) , 57-64
- https://doi.org/10.1007/bf01259410
Abstract
The influence of acute and repeated treatment with imipramine, amitriptyline, mianserin, citalopram and ECS on α1-adrenoceptors in different structures of the rat brain (cerebral cortex, hippocampus and thalamus) was measured using [3H] prazosin as a ligand. Repeated, but not acute, treatment with all the above antidepressant drugs and ECS induced an increase in the density of α1-adrenoceptors in the cerebral cortex. On the other hand, no changes were found in the hippocampus and thalamus, with an exception of the increased number of [3H] prazosin binding sites in the thalamus after imipramine. The results suggest that the up-regulation of α1-adrenoceptors following repeated antidepressant treatment is not a general phenomenon within the central nervous system.Keywords
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