Reduced lethality in mice receiving a combined dose of cyclophosphamide and busulphan
- 1 August 1975
- journal article
- Published by Springer Nature in British Journal of Cancer
- Vol. 32 (2) , 193-198
- https://doi.org/10.1038/bjc.1975.149
Abstract
Animals treated with a sufficiently high dose of busulphan die about 14 days later from bone marrow failure. A single, appropriately timed injection of cyclophosphamide can save these mice. The nature of this protection is shown to be the cyclophosphamide induced elaboration of a humoral factor which stimulates haemopoietic recovery.Keywords
This publication has 14 references indexed in Scilit:
- THE EFFECT OF FETUIN AND OF SPLEEN EXTRACTS ON HEMATOPOIETIC PRECURSORS AND ON DIFFERENTIATED HEMATOPOIETIC CELLS IN IRRADIATED MICECell Proliferation, 1974
- EFFECT OF CYCLOPHOSPHAMIDE ON THE HEMATOPOIETIC MICROENVIRONMENTAL FACTORS WHICH INFLUENCE HEMATOPOIETIC STEM CELL PROLIFERATIONCell Proliferation, 1973
- Survival of rat bone marrow cells after treatment with myleran and endoxan.1973
- Effect of Endotoxin on Granulopoiesis and Colony-Stimulating FactorNew England Journal of Medicine, 1972
- The effect of a homologous series of dimethane-sulphonoxy-alanes on haemopoietic colony forming units in the ratChemico-Biological Interactions, 1970
- On Mouse Strain Differences in Radiation Resistance: Hematopoietic Death and the Endogenous Colony-Forming UnitRadiation Research, 1969
- The Effect of Cyclophosphamide on Hematopoietic Stem CellsRadiation Research, 1968
- THE GROWTH OF MOUSE BONE MARROW CELLS IN VITROImmunology & Cell Biology, 1966
- Effects of Bacterial Endotoxin on the Occurrence of Spleen Colonies in Irradiated MiceRadiation Research, 1966
- The cloning of normal “Mast” cells in tissue cultureJournal of Cellular and Comparative Physiology, 1965