Rapid Oligosaccharide Synthesis Using a Fluorous Protective Group
- 3 July 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 69 (16) , 5348-5353
- https://doi.org/10.1021/jo049425k
Abstract
The Bfp-OH, a novel fluorous protecting reagent, was able to be easily prepared. The Bfp group was readily introduced to a carbohydrate, removed in high yield, and recyclable after cleavage. The use of the Bfp group made it possible to synthesize a pentasaccharide by minimal column chromatography purification. Each synthetic intermediate was able to be easily purified only by simple fluorous−organic solvent extraction and monitored by TLC, NMR, and MS.Keywords
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