Clioquinol: availability and instructions for use

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Abstract
Clioquinol †is widely available as an over-the-counter drug for the prophylaxis and treatment of travellers' diarrhoea. Yet there is very little reliable evidence that it is effective against this disorder. Furthermore, its use has some disadvantages and has been associated with damage to the nervous system, in particular with an epidemic of subacute myelo-optic neuropathy in Japan An analysis of package leaflets from 83 samples obtained from 35 countries shows wide variation in the dosage, duration of treatment, contraindications, side effects and warnings listed. We conclude that manufacturers should provide simplified and uniform instructions incorporating the most rigorous warnings currently given in some leaflets.

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