SELECTIVE SYMPATHETIC DENERVATION OF THE RABBIT DUCTUS DEFERENS USING 6-HYDROXYDOPAMINE

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Abstract
The male reproductive tract receives a rich adrenergic innervation (Sjöstrand, 1965; Hodson, 1965; Norberg, Risley & Ungerstedt, 1967). Previous attempts to achieve denervation of the sympathetic supply to the ductus deferens required drastic surgical stripping of the serous coat and mesenteric attachments (Birmingham, 1970; Birmingham, Paterson & Wojcicki, 1970). Recently, Eddy & Black (1973) have shown that selective sympathectomy of the rabbit oviduct can be achieved with 6-hydroxydopamine. The present study was designed to evaluate this denervation method in the rabbit ductus deferens. Thirty-eight mature Dutch-belted male rabbits were utilized in this study. The perfusion method of Eddy & Black (1973) was modified for application to the ductus deferens. Varying concentrations of 6-hydroxydopamine hydrobromide (6-OH-DA: Regis Chemical Co.) in 0·9% sterile ascorbic saline (0·5 mg ascorbic acid/ml) were individually perfused through one ductus deferens of each rabbit (Table

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