Further studies on the cysteine–cystine content of the foetal-human haemoglobin

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Abstract
Previous reports that only 4 of the total number of 6 half-cystine residues present in fetal-human hemoglobin are reactive sulfhydryl groups were confirmed by 2 other techniques. After reduction with thioglycollic acid reduced fetal hemoglobin was studied by paper and moving-boundary electrophoresis. With both techniques 2 different components were found. These results support the hypothesis that fetal-human hemoglobin is built up of 2 different polypeptide chains connected at least to each other by one disulfide bridge.