PROTEIN SECONDARY STRUCTURE - STUDIES ON THE LIMITS OF PREDICTION ACCURACY
- 1 January 1982
- journal article
- research article
- Vol. 19 (4) , 394-401
Abstract
A secondary structure prediction technique is proposed which includes nucleation site determination through multiplication of conformational preference parameters as well as weighting factors to represent structurally stabilizing short range interactions. The prediction accuracy of the method is calculated using data bases categorized according to the 4 protein structural classes and with differing assignments of secondary structural regions. Nearest neighbor prediction techniques are insensitive to various assignment criteria for the secondary structural spans, have nearly achieved their upper limit of prediction accuracy, and can be somewhat improved through the use of stereochemical weighting factors and conformational parameters derived from the 4 structural groups.This publication has 10 references indexed in Scilit:
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