PROSTATIC FLUID AND TISSUE CONCENTRATIONS OF AMPICILLIN AFTER ADMINISTRATION OF HETACILLIN ESTER (BL-P1761)

  • 1 January 1976
    • journal article
    • research article
    • Vol. 14  (1) , 57-59
Abstract
Ampicillin concentrations in prostatic fluid and tissue were studied in dogs after constant i.v. infusion of ampicillin (3 dogs) and a lipid-soluble methoxymethyl ester of hetacillin, BL-P1761 (6 dogs). Prostatic fluid ampicillin concentrations as determined by bioassay were approximately 15 times higher after administration of hetacillin than after a similar amount of ampicillin. The prostatic fluid concentrations after hetacillin ester administration were approximately 1/2 of the simultaneous plasma concentrations. This hetacillin ester is thus the 1st penicillin compound penetrating the blood-prostatic fluid barrier, resulting in clinically relevant prostatic fluid concentrations.

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