Tor1 is a novel, variant form of mouse chromosome 17 with a deletion in a partial t haplotype

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Abstract
Moutier1 discovered, in a mouse from a noninbred Swiss/Orleans laboratory stock, a spontaneous dominant mutation which mapped to the T locus, and which was named Tor1. Genetic analyses indicated that Tor1 was not a simple mutation at one locus, but rather a deletion over a 3-centimorgan region of chromosome 17 that included both T and quaking (qk)2,3. Further experiments reported by Erickson et al.3, and a more comprehensive study by Hammerberg4, have demonstrated that Tor1 is associated with recessive genetic properties affecting sperm function, characteristic of the proximal region of complete t haplotypes. These results were interpreted as evidence for the location of proximal t haplotype ‘sperm factors’ within the region deleted by Tor1. We now provide conclusive biochemical and genetic evidence that the ‘Tor1 haplotype’ is inseparably associated with a chromosomal region derived from a naturally occurring mouse t haplotype. Hence, it is likely that the t haplotype properties of Tor1 are a consequence not of the deletion itself, but of closely linked mutant t haplotype genes.