Über Peptidsynthesen, IX. DARSTELLUNG UND REAKTIONEN DES CARBOBENZOXY‐l‐GLUTAMINSÄURE‐α‐THIOÄTHYLESTERS
- 27 March 1962
- journal article
- research article
- Published by Wiley in European Journal of Organic Chemistry
- Vol. 651 (1) , 194-205
- https://doi.org/10.1002/jlac.19626510124
Abstract
Durch Umsetzung von Carbobenzoxy‐L‐glutaminsäureanhydrid mit Äthylmercaptan in wasserfreiem Äther bei Gegenwart von Dicyclohexylamin erhält man in guter Ausbeute den Carbobenzoxy‐L‐glutaminsäure‐α‐thioäthylester (als Dicyclohexylammoniumsalz); dieser kann vorteilhaft für Glutamylpeptid‐Synthesen eingesetzt werden, wobei die α‐Thioester‐Gruppierung einmal als Schutzgruppe, zum anderen (gegenüber Ammoniak und Hydrazin) als aktivierter Rest fungieren kann.Keywords
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