Total Synthesis of Siastatin B and Its Enantiomer Using Carbohydrate as a Chiral Educt
- 1 April 1992
- journal article
- research article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 65 (4) , 978-986
- https://doi.org/10.1246/bcsj.65.978
Abstract
The enantioselective synthesis of siastatin B, an inhibitor of neuraminidase and its antipode from D-ribono-γ-lactone has stereospecifically been achieved. The total synthesis elucidated the absolute configuration of siastatin B as (3S,4S,5R,6R)-6-acetamido-4,5-dihydroxy-3-piperidinecarboxylic acid.Keywords
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