Distribution of Protein I, a Synapse‐Specific Phosphoprotein, and Adenylate Cyclase in the Rat Spinal Cord

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Abstract
The longitudinal and transverse distributions of the synapse-specific phosphoprotein protein I and adenylate cyclase in the rat spinal cord were studied. Protein I was enriched in all cervical and midlumbar (L3-L5) segments and sparse in midthoracic and sacral segments. Adenylate cyclase activity was high in all cervical and lumbosacral and low in midthoracic segments. Cross-sectionally, protein I and adenylate cyclase were more enriched in the dorsal half than in the ventral half in the various segments. The similar topographical distributions of protein I and adenylate cyclase in the spinal cord imply that adenylate cyclase may be intimately associated with protein I in the nervous system. It may regulate the state of in vivo phosphorylation of protein I through formation of cAMP.