Further Studies on the Availability of the Fluoride in Fish Protein Concentrate

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Abstract
In a previously published study using female weanling rats, the fluoride in FPC (fish protein concentrate) was shown to be about 25 to 50% as available as that in sodium fluoride, while in a study using adult male humans the availability of fluoride from the two sources was shown to be nearly the same. The present three experiments were conducted to determine the reasons for these conflicting results. In the first experiment at high intakes of fluoride, the apparent absorption of FPC-fluoride by weanling and adult male rats was 30 to 50% and the carcass retention was 30 to 60% as high as that of sodium fluoride. The comparative results for weanling and adult rats were similar. In the second experiment at low fluoride intakes, the apparent absorption and carcass retention of fluoride from FPC was similar to that from sodium fluoride. In the third experiment at low fluoride, calcium and phosphorus intakes, the apparent absorption and carcass retentions were higher for both sources of fluoride compared to the previous experiment. These studies showed that the availability and retention of FPC-fluoride were similar to those of sodium fluoride at low fluoride intakes. At high intakes, the availability of FPC-fluoride was less than 50% of that of sodium fluoride. Thus we conclude that the major reason for the differences in the two previously published studies was the level of fluoride intake as well as the level of calcium and phosphorus in the diets.