Vitamin K Deficiency in Breast-Fed Infants at One Month of Age
- 1 November 1986
- journal article
- research article
- Published by Wiley in Journal of Pediatric Gastroenterology and Nutrition
- Vol. 5 (6) , 931-933
- https://doi.org/10.1097/00005176-198611000-00019
Abstract
PIVKA-II (protein induced by vitamin K absence or antagonist-II) was measured, as an indicator of vitamin K deficiency, in breast-fed infants of .apprx. 1 month of age. The infants consisted of three different groups: untreated (group 1); those given 5 mg vitamin K once at birth (group 2); and those given 5 mg twice, at birth and at 14 days after birth (group 3). At 1 month of age, the rate of PIVKA-II-positive infants and their PIVKA-II levels were significantly reduced in group 3 as compared with the levels of the other two groups, whereas these parameters were similar between groups 1 and 2. This observation suggested that vitamin K administration once at birth may be unsafe by 1 month of age. An additional administration of vitamin K seemed to be necessary for complete prevention of vitamin K deficiency, causing severe bleeding in breast-fed infants of .apprx. 1 month of age.This publication has 4 references indexed in Scilit:
- EFFECT OF VITAMIN K ADMINISTRATION ON ACARBOXY PROTHROMBIN (PIVKA-II) LEVELS IN NEWBORNSThe Lancet, 1985
- Detection of Vitamin K Deficiency by Use of an Enzyme-Linked Immunosorbent Assay for Circulating Abnormal ProthrombinPediatric Research, 1985
- Intracranial hemorrhage and vitamin K deficiency in early infancyThe Journal of Pediatrics, 1984
- Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodiesAnalytical Biochemistry, 1966